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Gene Report for SPG00000008_2.0
Identity
Gene
Glutathione peroxidase 5 (GPx5)
Species
Homo sapiens
(Human)
Description
This gene belongs to the glutathione peroxidase family. It is specifically expressed in the epididymis in the mammalian male reproductive tract, and is androgen-regulated. Unlike mRNAs for other characterized glutathione peroxidases, this mRNA does not contain a selenocysteine (UGA) codon. Thus, the encoded protein is selenium-independent, and has been proposed to play a role in protecting the membranes of spermatozoa from the damaging effects of lipid peroxidation and/or preventing premature acrosome reaction. (
NCBI
)
Family
Glutathione peroxidase
Synonyms
None
Subfamily
Glutathione peroxidase 5 (GPx5)
Synonyms
None
Gene ID
SPG00000008
Gene release
2.0
External ID
ENSG00000224586.2
(
Ensembl
)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A)
[
Report annotation error
]
Curated external database annotation (GENCODE, 15)
[
Report annotation error
]
Conceptual translation (Translate, Standard code with Sec)
[
Report annotation error
]
Orientation
Forward
Structure
Feature
Col
Promoter
Col
Coding exon
Col
Non coding exon (UTR)
Col
Intron
Col
SECIS
Residue
Col
Sec
Col
Cys or Other
Gene
Transcript(s)
Promoter(s)
Protein(s)
Secis
SPT00000032_2.0
SPR00000040_2.0
SPP00000036_2.0
N/A
SPT00000033_2.0
SPR00000041_2.0
SPP00000037_2.0
N/A
Genetic
Differentiation
F
ST
Africa
Middle East
Europe
Central-South Asia
East Asia
Oceania
America
Africa
0.379
Middle East
0.709
0.631
Europe
0.610
0.518
0.448
Central-South Asia
0.581
0.586
0.530
0.486
East Asia
0.456
0.380
0.466
0.316
0.312
Oceania
0.449
0.231
0.281
0.261
0.472
0.597
America
0.264
0.190
0.231
0.143
0.092
0.357
0.184
High F
ST
Low F
ST
P-value
Africa
Middle East
Europe
Central-South Asia
East Asia
Oceania
America
Africa
0.227
Middle East
0.011
0.169
Europe
0.000
0.047
0.013
Central-South Asia
0.003
0.004
0.000
0.002
East Asia
0.000
0.000
0.000
0.000
0.000
Oceania
0.116
0.550
0.621
0.542
0.054
0.167
America
0.907
0.354
0.176
0.856
1.000
0.286
0.441
Low P-value
High P-value
Sequence
Sequence
SEQ00000008_2.0
External ID
ENSG00000224586.2
(
Ensembl
)
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Cite
S. Castellano, V.N. Gladyshev, R. Guigó and M.J. Berry
SelenoDB: a database of selenoprotein genes, proteins and SECIS elements
Unpublished
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