SelenoDB
Release 2.0
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Gene Report for SPG00000028_2.0
Identity
GeneMethionine-R-sufoxide reductase 3 (SelR3)
SpeciesHomo sapiens (Human)
DescriptionThe protein encoded by this gene catalyzes the reduction of methionine sulfoxide to methionine. This enzyme acts as a monomer and requires zinc as a cofactor. Several transcript variants encoding two different isoforms have been found for this gene. One of the isoforms localizes to mitochondria while the other localizes to endoplasmic reticula. (NCBI)
FamilySelenoprotein R
Synonyms Selenoprotein X (SelX)
Selenoprotein R (SEPR)
Subfamily Methionine-R-sufoxide reductase 3 (SelR3)
Synonyms Methionine-R-sulfoxide reductase 3 (MsrB3)
Gene IDSPG00000028
Gene release2.0
External ID ENSG00000174099.6 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000086_2.0SPR00000114_2.0SPP00000092_2.0N/A
SPT00000087_2.0SPR00000115_2.0SPP00000093_2.0N/A
SPT00000088_2.0SPR00000116_2.0SPP00000094_2.0N/A
SPT00000089_2.0SPR00000117_2.0SPP00000095_2.0N/A
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.455
Middle East0.5540.448
Europe0.5530.5140.465
Central-South Asia0.5690.5390.5030.507
East Asia0.3920.3730.3920.3300.330
Oceania0.4180.4520.4450.4170.4110.317
America0.3470.3950.3870.3720.3770.4480.264

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.011
Middle East0.6250.423
Europe0.0080.0230.012
Central-South Asia0.0070.0160.0000.002
East Asia0.0330.0000.0000.0000.000
Oceania0.3000.0500.0540.0490.1930.333
America0.2330.0010.0010.0000.0000.1480.367

Low P-value

High P-value

Sequence
Sequence SEQ00000028_2.0
External ID ENSG00000174099.6 (Ensembl)
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