SelenoDB
Release 2.0
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Gene Report for SPG00000037_2.0
Identity
GeneThioredoxin reductase 1 (TR1)
SpeciesHomo sapiens (Human)
DescriptionThis gene encodes a member of the family of pyridine nucleotide oxidoreductases. This protein reduces thioredoxins as well as other substrates, and plays a role in selenium metabolism and protection against oxidative stress. The functional enzyme is thought to be a homodimer which uses FAD as a cofactor. (NCBI)
FamilyThioredoxin reductase
Synonyms Thioredoxin reductase (TrxR)
Subfamily Thioredoxin reductase 1 (TR1)
Synonyms Gene associated with retinoid-IFN-induced mortality (GRIM-12)
Thioredoxin reductase 1 (TrxR1)
Gene IDSPG00000037
Gene release2.0
External ID ENSG00000198431.10 (Ensembl)
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
Curated external database annotation (GENCODE, 15) [Report annotation error]
Thermodynamic pattern-based SECIS prediction (SECISearch, 3.0) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationForward
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00000121_2.0SPR00000158_2.0SPP00000129_2.0SPS00000041_2.0
SPT00000123_2.0SPR00000160_2.0SPP00000131_2.0SPS00000042_2.0
SPT00000124_2.0SPR00000161_2.0SPP00000132_2.0SPS00000043_2.0
SPT00000126_2.0SPR00000163_2.0SPP00000134_2.0SPS00000044_2.0
Genetic
Differentiation
FST
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.243
Middle East0.6440.548
Europe0.5470.4590.406
Central-South Asia0.4830.4540.4170.402
East Asia0.4770.3740.3890.3860.340
Oceania0.4100.3140.3690.3410.4890.580
America0.3610.2590.2820.2750.2990.4470.332

High FST

Low FST

P-value
AfricaMiddle EastEuropeCentral-South AsiaEast AsiaOceaniaAmerica
Africa0.729
Middle East0.2250.256
Europe0.0310.0650.030
Central-South Asia0.4550.2210.0160.037
East Asia0.0000.0000.0000.0000.000
Oceania0.3170.2140.1860.1510.0240.167
America0.2520.1030.1050.0150.0030.1730.150

Low P-value

High P-value

Sequence
Sequence SEQ00000037_2.0
External ID ENSG00000198431.10 (Ensembl)
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