SelenoDB
Release 2.0
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Gene Report for SPG00001162_2.0
Identity
GeneThioredoxin reductase 2 (TR2)
SpeciesLatimeria chalumnae (Coelacanth)
DescriptionThioredoxin reductase (TR) is a dimeric NADPH-dependent FAD containing enzyme that catalyzes the reduction of the active site disulfide of thioredoxin and other substrates. TR is a member of a family of pyridine nucleotide-disulfide oxidoreductases and is a key enzyme in the regulation of the intracellular redox environment. Three thioredoxin reductase genes have been found that encode selenocysteine containing proteins. This gene partially overlaps the COMT gene on chromosome 22. (NCBI)
FamilyThioredoxin reductase
Synonyms Thioredoxin reductase (TrxR)
Subfamily Thioredoxin reductase 2 (TR2)
Synonyms Selenoprotein Z (SelZ)
Thioredoxin reductase 3 (TR3)
Thioredoxin reductase 2 (TrxR2)
Gene IDSPG00001162
Gene release2.0
External IDNone
Annotation
Prediction method(s)
Promoter prediction (5000bp upstream, N/A) [Report annotation error]
(Selenoprofiles, Ensembl 68) [Report annotation error]
Conceptual translation (Translate, Standard code with Sec) [Report annotation error]
OrientationReverse
Structure gene structure

FeatureCol PromoterCol Coding exonCol Non coding exon (UTR)Col IntronCol SECIS
ResidueCol SecCol Cys or Other

Gene
Transcript(s) Promoter(s) Protein(s) Secis
SPT00001258_2.0SPR00001323_2.0SPP00001266_2.0N/A
Sequence
Sequence SEQ00001161_2.0
External IDNone
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